Pixar's Ed Catmull likes to say that since you can't control the luck itself, which is bound to come your way for better and for worse, what matters is your state of preparedness to deal with it.
Remembering that I'll be dead soon is the most important tool I've ever encountered to help me make the big choices in life. Because almost everything-- all external expectations, all pride, all fear of embarrassment or failure--these things just fall away in the face of death, leaving only what is truly important. Remembering that you are going to die is the best way I know to avoid the trap of thinking you have something to lose. You are already naked. There is no reason not to follow your heart.